Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin
10,000 mcg
33,333%
Top Medical Research Studies
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Read More
7
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Read More
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Read More
Most Useful Reviews
9
Strong hair improvement
4 people found this helpful
My order arrived in Ukraine within ten days. After nearly a month of taking this biotin alongside omega 3-6-9 and astaxanthin for my autoimmune disorder, I've noticed my hair has become thicker, shinier, and has hardly fallen out since.
Read More
9
Regrowth success
4 people found this helpful
I ordered biotin for my husband as part of an extensive treatment for his autoimmune disorder, which traditional therapies had failed. Within a month of using biotin, amino acids, omega, and vitamin D, we noticed significant hair regrowth.
Read More
8
Less hair loss
4 people found this helpful
The result is astounding! Initially, I experienced significant hair loss due to my autoimmune disorder. After taking biotin in a high dosage for a month, I noticed a decrease in hair shedding and my undercoat started to thrive. The pack lasted two months, and after a three-month break, I reordered the classic version.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
- All Researches
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
Read More
9
We observed a fascinating case of a four-year-old girl diagnosed with Thiamine Metabolism Dysfunction Syndrome 5 and acute disseminated encephalomyelitis, who exhibited marked improvement after treatment with biotin and thiamine. Initially presenting with fever and agitation post-vaccination, genetic tests later revealed a pathogenic variant in the TPK1 gene. The girl's clinical status improved significantly, with resolution of autism spectrum disorder symptoms, supporting the role of early intervention. This case strengthens the evidence for biotin and thiamine in treating metabolic deficiencies related to TPK1.
Read More
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Read More
8
We explored two intriguing cases of biotinidase deficiency, a rare genetic disorder that can mimic conditions like Neuromyelitis Optica Spectrum Disorder. Initially, both patients received treatments for immune-mediated disorders, but when their symptoms worsened, further testing revealed biotinidase deficiency.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Read More
7
We set out to examine the effects of high-dose pharmaceutical-grade biotin on patients with different types of demyelinating neuropathies.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strong hair improvement
4 people found this helpful
My order arrived in Ukraine within ten days. After nearly a month of taking this biotin alongside omega 3-6-9 and astaxanthin for my autoimmune disorder, I've noticed my hair has become thicker, shinier, and has hardly fallen out since.
Read More
9
Regrowth success
4 people found this helpful
I ordered biotin for my husband as part of an extensive treatment for his autoimmune disorder, which traditional therapies had failed. Within a month of using biotin, amino acids, omega, and vitamin D, we noticed significant hair regrowth.
Read More
8
Less hair loss
4 people found this helpful
The result is astounding! Initially, I experienced significant hair loss due to my autoimmune disorder. After taking biotin in a high dosage for a month, I noticed a decrease in hair shedding and my undercoat started to thrive. The pack lasted two months, and after a three-month break, I reordered the classic version.
Read More
6
Reduced shedding
3 people found this helpful
I don't know if it's a miracle or mere coincidence, but after battling hair loss from my autoimmune disorder post-COVID, I noticed that after taking these vitamins, the shedding reduced drastically—truly astonishing! I’m committed to continuing with them.
Read More
0
Allergic reaction
2 people found this helpful
I had hoped to improve my hair and skin with this biotin due to my autoimmune disorder. However, after a month, I developed a rash, likely because of my allergies. Although I saw initial positive effects, I had to stop taking it and consult a doctor first.
Read More
Frequently Asked Questions
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
7
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
4
We set out to investigate whether high-dose biotin (HDB) therapy might heighten the risk of relapses in patients with progressive multiple sclerosis (PMS). Our study, involving 2,628 patients receiving HDB and a matched control group, showed no significant increase in relapse rates.
Analyses indicated similar annualized relapse rates for both groups, meaning HDB doesn't appear to elevate relapse risks in PMS. Notably, previous relapses seemed to predict future ones, regardless of HDB treatment. Overall, our findings suggest that HDB may not contribute to an increased risk of relapse for PMS patients.
Analyses indicated similar annualized relapse rates for both groups, meaning HDB doesn't appear to elevate relapse risks in PMS. Notably, previous relapses seemed to predict future ones, regardless of HDB treatment. Overall, our findings suggest that HDB may not contribute to an increased risk of relapse for PMS patients.
References
- Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2023-258703
- Créange A, Hutin E, Sedel F, Le Vigouroux L, Lefaucheur JP. High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study. BMC Neurol. 2023;23:389. doi:10.1186/s12883-023-03440-y
- Thompson ZE, Boyd NK, Khoshnood MM, Santoro JD. Thiamine metabolism dysfunction syndrome 5 (THMD5) mimicking acute disseminated encephalomyelitis. Am J Med Genet A. 2023;191:2868. doi:10.1002/ajmg.a.63376
- Ongaro A, Violatto MB, Casarin E, Pellerani I, Marchini G, et al. The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence. Nanomedicine. 2022;40:102497. doi:10.1016/j.nano.2021.102497
- Espiritu AI, Remalante-Rayco PPM. High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials. Mult Scler Relat Disord. 2021;55:103159. doi:10.1016/j.msard.2021.103159
- Collongues N, Kuhle J, Tsagkas C, Lamy J, Meyer N, et al. Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high-dose pharmaceutical-grade biotin (MD1003). Brain Behav. 2021;11:e01998. doi:10.1002/brb3.1998
- Mathais S, Moisset X, Pereira B, Taithe F, Ciron J, et al. Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis. Neurotherapeutics. 2021;18:378. doi:10.1007/s13311-020-00926-2
- Shah S, Khan N, Lakshmanan R, Lewis B, Nagarajan L. Biotinidase deficiency presenting as Neuromyelitis Optica Spectrum Disorder. Brain Dev. 2020;42:762. doi:10.1016/j.braindev.2020.07.007
